diff --git a/mysql-test/r/gis-rtree.result b/mysql-test/r/gis-rtree.result
index 92fcbfcdc9e..dbd6783fe76 100644
--- a/mysql-test/r/gis-rtree.result
+++ b/mysql-test/r/gis-rtree.result
@@ -862,3 +862,14 @@ CHECK TABLE t1 EXTENDED;
 Table	Op	Msg_type	Msg_text
 test.t1	check	status	OK
 DROP TABLE t1;
+CREATE TABLE t1 (foo GEOMETRY NOT NULL, SPATIAL INDEX(foo) );
+INSERT INTO t1 (foo) VALUES (PointFromWKB(POINT(1,1)));
+INSERT INTO t1 (foo) VALUES (PointFromWKB(POINT(1,0)));
+INSERT INTO t1 (foo) VALUES (PointFromWKB(POINT(0,1)));
+INSERT INTO t1 (foo) VALUES (PointFromWKB(POINT(0,0)));
+SELECT 1 FROM t1 WHERE foo != PointFromWKB(POINT(0,0));
+1
+1
+1
+1
+DROP TABLE t1;
diff --git a/mysql-test/t/gis-rtree.test b/mysql-test/t/gis-rtree.test
index 163f2806ad2..09cdcb2435e 100644
--- a/mysql-test/t/gis-rtree.test
+++ b/mysql-test/t/gis-rtree.test
@@ -231,4 +231,14 @@ INSERT INTO t1 (c1) VALUES (
 CHECK TABLE t1 EXTENDED;
 DROP TABLE t1;
 
+#
+# Bug #21888: Query on GEOMETRY field using PointFromWKB() results in lost connection
+#
+CREATE TABLE t1 (foo GEOMETRY NOT NULL, SPATIAL INDEX(foo) );
+INSERT INTO t1 (foo) VALUES (PointFromWKB(POINT(1,1)));
+INSERT INTO t1 (foo) VALUES (PointFromWKB(POINT(1,0)));
+INSERT INTO t1 (foo) VALUES (PointFromWKB(POINT(0,1)));
+INSERT INTO t1 (foo) VALUES (PointFromWKB(POINT(0,0)));
+SELECT 1 FROM t1 WHERE foo != PointFromWKB(POINT(0,0));
+DROP TABLE t1;
 # End of 4.1 tests
diff --git a/storage/myisam/mi_range.c b/storage/myisam/mi_range.c
index e78f3b11625..a28aed81aec 100644
--- a/storage/myisam/mi_range.c
+++ b/storage/myisam/mi_range.c
@@ -71,6 +71,21 @@ ha_rows mi_records_in_range(MI_INFO *info, int inx, key_range *min_key,
     uchar * key_buff;
     uint start_key_len;
 
+    /*
+      The problem is that the optimizer doesn't support
+      RTree keys properly at the moment.
+      Hope this will be fixed some day.
+      But now NULL in the min_key means that we
+      didn't make the task for the RTree key
+      and expect BTree functionality from it.
+      As it's not able to handle such request
+      we return the error.
+    */
+    if (!min_key)
+    {
+      res= HA_POS_ERROR;
+      break;
+    }
     key_buff= info->lastkey+info->s->base.max_key_length;
     start_key_len= _mi_pack_key(info,inx, key_buff,
                                 (uchar*) min_key->key, min_key->length,