diff --git a/mysql-test/main/alter_table.result b/mysql-test/main/alter_table.result
index d44094b791b..1cad2f14a41 100644
--- a/mysql-test/main/alter_table.result
+++ b/mysql-test/main/alter_table.result
@@ -3415,23 +3415,5 @@ ERROR 0A000: ALGORITHM=INPLACE is not supported for this operation. Try ALGORITH
 delete from t1 where a = 11;
 drop table t1;
 #
-# MDEV-23836: Assertion `! is_set() || m_can_overwrite_status' in
-# Diagnostics_area::set_error_status (interrupted ALTER TABLE under LOCK)
-#
-SET @max_session_mem_used_save= @@max_session_mem_used;
-CREATE TABLE t1 (a INT);
-SELECT * FROM t1;
-a
-ALTER TABLE x MODIFY xx INT;
-ERROR 42S02: Table 'test.x' doesn't exist
-SET SESSION max_session_mem_used= 8192;
-LOCK TABLE t1 WRITE;
-ALTER TABLE t1 CHANGE COLUMN IF EXISTS b c INT;
-Warnings:
-Note	1054	Unknown column 'b' in 't1'
-SET SESSION max_session_mem_used = @max_session_mem_used_save;
-UNLOCK TABLES;
-DROP TABLE t1;
-#
 # End of 10.5 tests
 #
diff --git a/mysql-test/main/alter_table.test b/mysql-test/main/alter_table.test
index cc17c3efec9..1bff20a7bd7 100644
--- a/mysql-test/main/alter_table.test
+++ b/mysql-test/main/alter_table.test
@@ -2661,28 +2661,6 @@ delete from t1 where a = 11;
 # cleanup
 drop table t1;
 
---echo #
---echo # MDEV-23836: Assertion `! is_set() || m_can_overwrite_status' in
---echo # Diagnostics_area::set_error_status (interrupted ALTER TABLE under LOCK)
---echo #
-
-SET @max_session_mem_used_save= @@max_session_mem_used;
-
-CREATE TABLE t1 (a INT);
-SELECT * FROM t1;
-
---error ER_NO_SUCH_TABLE
-ALTER TABLE x MODIFY xx INT;
-
-SET SESSION max_session_mem_used= 8192;
-LOCK TABLE t1 WRITE;
-
-ALTER TABLE t1 CHANGE COLUMN IF EXISTS b c INT;
-
-SET SESSION max_session_mem_used = @max_session_mem_used_save;
-UNLOCK TABLES;
-DROP TABLE t1;
-
 --echo #
 --echo # End of 10.5 tests
 --echo #
diff --git a/mysql-test/main/alter_table_lock.result b/mysql-test/main/alter_table_lock.result
new file mode 100644
index 00000000000..ce6097c9ada
--- /dev/null
+++ b/mysql-test/main/alter_table_lock.result
@@ -0,0 +1,19 @@
+#
+# MDEV-23836: Assertion `! is_set() || m_can_overwrite_status' in
+# Diagnostics_area::set_error_status (interrupted ALTER TABLE under LOCK)
+#
+SET @max_session_mem_used_save= @@max_session_mem_used;
+CREATE TABLE t1 (a INT);
+SELECT * FROM t1;
+a
+ALTER TABLE x MODIFY xx INT;
+ERROR 42S02: Table 'test.x' doesn't exist
+SET SESSION max_session_mem_used= 8192;
+LOCK TABLE t1 WRITE;
+ALTER TABLE t1 CHANGE COLUMN IF EXISTS b c INT;
+Warnings:
+Note	1054	Unknown column 'b' in 't1'
+SET SESSION max_session_mem_used = @max_session_mem_used_save;
+UNLOCK TABLES;
+DROP TABLE t1;
+# End of 10.5 tests
diff --git a/mysql-test/main/alter_table_lock.test b/mysql-test/main/alter_table_lock.test
new file mode 100644
index 00000000000..f1f60e38b61
--- /dev/null
+++ b/mysql-test/main/alter_table_lock.test
@@ -0,0 +1,25 @@
+--source include/not_msan.inc
+
+--echo #
+--echo # MDEV-23836: Assertion `! is_set() || m_can_overwrite_status' in
+--echo # Diagnostics_area::set_error_status (interrupted ALTER TABLE under LOCK)
+--echo #
+
+SET @max_session_mem_used_save= @@max_session_mem_used;
+
+CREATE TABLE t1 (a INT);
+SELECT * FROM t1;
+
+--error ER_NO_SUCH_TABLE
+ALTER TABLE x MODIFY xx INT;
+
+SET SESSION max_session_mem_used= 8192;
+LOCK TABLE t1 WRITE;
+
+ALTER TABLE t1 CHANGE COLUMN IF EXISTS b c INT;
+
+SET SESSION max_session_mem_used = @max_session_mem_used_save;
+UNLOCK TABLES;
+DROP TABLE t1;
+
+--echo # End of 10.5 tests
diff --git a/mysql-test/main/cte_recursive.test b/mysql-test/main/cte_recursive.test
index f8c41dbc3ea..5964c32061b 100644
--- a/mysql-test/main/cte_recursive.test
+++ b/mysql-test/main/cte_recursive.test
@@ -1,4 +1,7 @@
 --source include/default_optimizer_switch.inc
+# This is too slow on MSAN
+--source include/not_msan.inc
+--source include/not_valgrind.inc
 
 create table t1 (a int, b varchar(32));
 insert into t1 values
diff --git a/mysql-test/main/partition_debug_sync.result b/mysql-test/main/partition_debug_sync.result
index 7006491fcaa..635f7735e6c 100644
--- a/mysql-test/main/partition_debug_sync.result
+++ b/mysql-test/main/partition_debug_sync.result
@@ -53,9 +53,14 @@ SET DEBUG_SYNC= 'alter_table_before_rename_result_table WAIT_FOR delete_done';
 ALTER TABLE t2 REMOVE PARTITIONING;
 connection default;
 SET DEBUG_SYNC= 'now WAIT_FOR removing_partitions';
-SET DEBUG_SYNC= 'rm_table_no_locks_before_delete_table SIGNAL waiting_for_alter';
+SET DEBUG_SYNC= 'rm_table_no_locks_before_delete_table SIGNAL waiting_for_alter WAIT_FOR mtr_continue';
 SET DEBUG_SYNC= 'rm_table_no_locks_before_binlog SIGNAL delete_done';
 DROP TABLE IF EXISTS t2;
+# Create a new connection thread to orchestrate the ALTER and DROP
+# threads' DEBUG_SYNC points to avoid lost signals
+connect con2,localhost,root,,;
+SET DEBUG_SYNC= 'now SIGNAL mtr_continue';
+connection default;
 connection con1;
 ERROR 42S02: Table 'test.t2' doesn't exist
 SET DEBUG_SYNC= 'RESET';
diff --git a/mysql-test/main/partition_debug_sync.test b/mysql-test/main/partition_debug_sync.test
index 09ebba0b0e2..bc49153f803 100644
--- a/mysql-test/main/partition_debug_sync.test
+++ b/mysql-test/main/partition_debug_sync.test
@@ -66,12 +66,27 @@ SET DEBUG_SYNC= 'alter_table_before_rename_result_table WAIT_FOR delete_done';
 --send ALTER TABLE t2 REMOVE PARTITIONING
 connection default;
 SET DEBUG_SYNC= 'now WAIT_FOR removing_partitions';
-SET DEBUG_SYNC= 'rm_table_no_locks_before_delete_table SIGNAL waiting_for_alter';
+
+SET DEBUG_SYNC= 'rm_table_no_locks_before_delete_table SIGNAL waiting_for_alter WAIT_FOR mtr_continue';
 SET DEBUG_SYNC= 'rm_table_no_locks_before_binlog SIGNAL delete_done';
-DROP TABLE IF EXISTS t2;
+--send DROP TABLE IF EXISTS t2
+
+--echo # Create a new connection thread to orchestrate the ALTER and DROP
+--echo # threads' DEBUG_SYNC points to avoid lost signals
+connect(con2,localhost,root,,);
+let $wait_condition= select count(*)=0 from information_schema.processlist where state like "debug sync point: alter_table_before_open_tables";
+source include/wait_condition.inc;
+SET DEBUG_SYNC= 'now SIGNAL mtr_continue';
+
+# Return execution for DROP TABLE
+connection default;
+--reap
+
+# Return execution for ALTER TABLE
 connection con1;
 --error ER_NO_SUCH_TABLE
 --reap
+
 SET DEBUG_SYNC= 'RESET';
 disconnect con1;
 --source include/wait_until_disconnected.inc
diff --git a/mysql-test/main/query_cache_debug.test b/mysql-test/main/query_cache_debug.test
index 90b76077cac..af82927245b 100644
--- a/mysql-test/main/query_cache_debug.test
+++ b/mysql-test/main/query_cache_debug.test
@@ -197,8 +197,17 @@ SET DEBUG_SYNC="now WAIT_FOR parked1_2";
 --echo ** and finally release the mutex. The threads will continue to wait
 --echo ** until a broadcast signal reaches them causing both threads to 
 --echo ** come alive and check the condition.
+
+# Before sending signals back-to-back, we have to ensure the previous signal
+# was received
+let $wait_condition= select count(*)=3 from information_schema.processlist where state like "%debug%";
+source include/wait_condition.inc;
 SET DEBUG_SYNC="now SIGNAL go2";
+let $wait_condition= select count(*)=2 from information_schema.processlist where state like "%debug%";
+source include/wait_condition.inc;
 SET DEBUG_SYNC="now SIGNAL go3";
+let $wait_condition= select count(*)=1 from information_schema.processlist where state like "%debug%";
+source include/wait_condition.inc;
 
 --echo **
 --echo ** Finally signal the DELETE statement on THD1 one last time.
@@ -208,6 +217,8 @@ SET DEBUG_SYNC="now SIGNAL go3";
 --echo ** invalidations and a broadcast signal will be sent to the thread 
 --echo ** group holding result set writers.
 SET DEBUG_SYNC="now SIGNAL go1_2";
+let $wait_condition= select count(*)=0 from information_schema.processlist where state like "%debug%";
+source include/wait_condition.inc;
 
 --echo **
 --echo *************************************************************************
diff --git a/mysql-test/main/ssl-big.test b/mysql-test/main/ssl-big.test
index 44db11b52bb..fa35146e627 100644
--- a/mysql-test/main/ssl-big.test
+++ b/mysql-test/main/ssl-big.test
@@ -6,6 +6,7 @@
 -- source include/have_64bit.inc
 # No point in running with valgrind as it takes 1.5 hours
 -- source include/not_valgrind.inc
+-- source include/not_msan.inc
 
 # Save the initial number of concurrent sessions
 --source include/count_sessions.inc
diff --git a/mysql-test/suite/innodb/t/redo_log_during_checkpoint.test b/mysql-test/suite/innodb/t/redo_log_during_checkpoint.test
index 85beb3ee1d2..40b412ac9bb 100644
--- a/mysql-test/suite/innodb/t/redo_log_during_checkpoint.test
+++ b/mysql-test/suite/innodb/t/redo_log_during_checkpoint.test
@@ -6,6 +6,8 @@
 # We are crashing the server on purpose
 --source include/not_valgrind.inc
 --source include/not_crashrep.inc
+# This often fails under MSAN builder due timing differences
+--source include/not_msan.inc
 
 # The test does work with any page size, but we want to reduce the
 # test running time by limiting the combinations. The redo log format
diff --git a/mysql-test/suite/rpl/t/rpl_dump_request_retry_warning.test b/mysql-test/suite/rpl/t/rpl_dump_request_retry_warning.test
index d750d44ae71..1ee043623ae 100644
--- a/mysql-test/suite/rpl/t/rpl_dump_request_retry_warning.test
+++ b/mysql-test/suite/rpl/t/rpl_dump_request_retry_warning.test
@@ -43,6 +43,12 @@ START SLAVE;
 SET DEBUG_SYNC= 'now WAIT_FOR parked';
 SET @@GLOBAL.debug_dbug = @saved_dbug;
 SET DEBUG_SYNC= 'now SIGNAL continue';
+
+# Ensure the last DEBUG_SYNC signal was received by the target thread before
+# reset; otherwise, the reset can drop the last signal before it gets
+# acknowledged
+let $wait_condition= select count(*)=0 from information_schema.processlist where state like "%debug%";
+source include/wait_condition.inc;
 SET DEBUG_SYNC= 'RESET';
 
 --source include/wait_for_slave_io_to_start.inc
diff --git a/storage/innobase/trx/trx0undo.cc b/storage/innobase/trx/trx0undo.cc
index 139e5ee1533..8382049820a 100644
--- a/storage/innobase/trx/trx0undo.cc
+++ b/storage/innobase/trx/trx0undo.cc
@@ -1,7 +1,7 @@
 /*****************************************************************************
 
 Copyright (c) 1996, 2016, Oracle and/or its affiliates. All Rights Reserved.
-Copyright (c) 2014, 2021, MariaDB Corporation.
+Copyright (c) 2014, 2022, MariaDB Corporation.
 
 This program is free software; you can redistribute it and/or modify it under
 the terms of the GNU General Public License as published by the Free Software
@@ -465,6 +465,10 @@ static uint16_t trx_undo_header_create(buf_block_t *undo_page, trx_id_t trx_id,
                   undo_page->page.frame, free);
   mtr->write<8,mtr_t::MAYBE_NOP>(*undo_page, free + TRX_UNDO_TRX_ID +
                                  undo_page->page.frame, trx_id);
+  if (UNIV_UNLIKELY(mach_read_from_8(free + TRX_UNDO_TRX_NO +
+                                     undo_page->page.frame)))
+    mtr->memset(undo_page, free + TRX_UNDO_TRX_NO, 8, 0);
+
   /* Write TRX_UNDO_NEEDS_PURGE=1 and TRX_UNDO_LOG_START. */
   mach_write_to_2(buf, 1);
   memcpy_aligned<2>(buf + 2, start, 2);
@@ -882,12 +886,19 @@ corrupted:
 		sql_print_error("InnoDB: unsupported undo header state %u",
 				state);
 		goto corrupted;
+	case TRX_UNDO_CACHED:
+		if (UNIV_UNLIKELY(type != 0)) {
+			/* This undo page was not updated by MariaDB
+			10.3 or later. The TRX_UNDO_TRX_NO field may
+			contain garbage. */
+			break;
+		}
+		goto read_trx_no;
 	case TRX_UNDO_TO_PURGE:
 		if (UNIV_UNLIKELY(type == 1)) {
 			goto corrupted_type;
 		}
-		/* fall through */
-	case TRX_UNDO_CACHED:
+	read_trx_no:
 		trx_id_t id = mach_read_from_8(TRX_UNDO_TRX_NO + undo_header);
 		if (id >> 48) {
 			sql_print_error("InnoDB: corrupted TRX_NO %llx", id);